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Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies
Filoviruses cause severe hemorrhagic fever in humans. The archetypal virus of this group, Ebola virus, is responsible for the current filovirus epidemic in West Africa. Filoviruses infect most mammalian cells, resulting in broad species tropism and likely contributing to rapid spread of virus throug...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617201/ https://www.ncbi.nlm.nih.gov/pubmed/26509109 http://dx.doi.org/10.1007/s40588-015-0021-3 |
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author | Rhein, Bethany A. Maury, Wendy J. |
author_facet | Rhein, Bethany A. Maury, Wendy J. |
author_sort | Rhein, Bethany A. |
collection | PubMed |
description | Filoviruses cause severe hemorrhagic fever in humans. The archetypal virus of this group, Ebola virus, is responsible for the current filovirus epidemic in West Africa. Filoviruses infect most mammalian cells, resulting in broad species tropism and likely contributing to rapid spread of virus throughout the body. A thorough understanding of filovirus entry events will facilitate the development of therapeutics against these critical steps in the viral life cycle. This review summarizes the current understanding of filovirus entry and discusses some of the recent advancements in therapeutic strategies that target entry. |
format | Online Article Text |
id | pubmed-4617201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-46172012016-09-01 Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies Rhein, Bethany A. Maury, Wendy J. Curr Clin Microbiol Rep Virology (A Nicola, Section Editor) Filoviruses cause severe hemorrhagic fever in humans. The archetypal virus of this group, Ebola virus, is responsible for the current filovirus epidemic in West Africa. Filoviruses infect most mammalian cells, resulting in broad species tropism and likely contributing to rapid spread of virus throughout the body. A thorough understanding of filovirus entry events will facilitate the development of therapeutics against these critical steps in the viral life cycle. This review summarizes the current understanding of filovirus entry and discusses some of the recent advancements in therapeutic strategies that target entry. Springer International Publishing 2015-07-01 2015 /pmc/articles/PMC4617201/ /pubmed/26509109 http://dx.doi.org/10.1007/s40588-015-0021-3 Text en © Springer International Publishing AG 2015 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Virology (A Nicola, Section Editor) Rhein, Bethany A. Maury, Wendy J. Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies |
title | Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies |
title_full | Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies |
title_fullStr | Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies |
title_full_unstemmed | Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies |
title_short | Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies |
title_sort | ebola virus entry into host cells: identifying therapeutic strategies |
topic | Virology (A Nicola, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617201/ https://www.ncbi.nlm.nih.gov/pubmed/26509109 http://dx.doi.org/10.1007/s40588-015-0021-3 |
work_keys_str_mv | AT rheinbethanya ebolavirusentryintohostcellsidentifyingtherapeuticstrategies AT maurywendyj ebolavirusentryintohostcellsidentifyingtherapeuticstrategies |