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Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies

Filoviruses cause severe hemorrhagic fever in humans. The archetypal virus of this group, Ebola virus, is responsible for the current filovirus epidemic in West Africa. Filoviruses infect most mammalian cells, resulting in broad species tropism and likely contributing to rapid spread of virus throug...

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Detalles Bibliográficos
Autores principales: Rhein, Bethany A., Maury, Wendy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617201/
https://www.ncbi.nlm.nih.gov/pubmed/26509109
http://dx.doi.org/10.1007/s40588-015-0021-3
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author Rhein, Bethany A.
Maury, Wendy J.
author_facet Rhein, Bethany A.
Maury, Wendy J.
author_sort Rhein, Bethany A.
collection PubMed
description Filoviruses cause severe hemorrhagic fever in humans. The archetypal virus of this group, Ebola virus, is responsible for the current filovirus epidemic in West Africa. Filoviruses infect most mammalian cells, resulting in broad species tropism and likely contributing to rapid spread of virus throughout the body. A thorough understanding of filovirus entry events will facilitate the development of therapeutics against these critical steps in the viral life cycle. This review summarizes the current understanding of filovirus entry and discusses some of the recent advancements in therapeutic strategies that target entry.
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spelling pubmed-46172012016-09-01 Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies Rhein, Bethany A. Maury, Wendy J. Curr Clin Microbiol Rep Virology (A Nicola, Section Editor) Filoviruses cause severe hemorrhagic fever in humans. The archetypal virus of this group, Ebola virus, is responsible for the current filovirus epidemic in West Africa. Filoviruses infect most mammalian cells, resulting in broad species tropism and likely contributing to rapid spread of virus throughout the body. A thorough understanding of filovirus entry events will facilitate the development of therapeutics against these critical steps in the viral life cycle. This review summarizes the current understanding of filovirus entry and discusses some of the recent advancements in therapeutic strategies that target entry. Springer International Publishing 2015-07-01 2015 /pmc/articles/PMC4617201/ /pubmed/26509109 http://dx.doi.org/10.1007/s40588-015-0021-3 Text en © Springer International Publishing AG 2015 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Virology (A Nicola, Section Editor)
Rhein, Bethany A.
Maury, Wendy J.
Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies
title Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies
title_full Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies
title_fullStr Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies
title_full_unstemmed Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies
title_short Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies
title_sort ebola virus entry into host cells: identifying therapeutic strategies
topic Virology (A Nicola, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617201/
https://www.ncbi.nlm.nih.gov/pubmed/26509109
http://dx.doi.org/10.1007/s40588-015-0021-3
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