The age factor in Alzheimer’s disease

Alzheimer’s disease is the most common type of dementia, and it is characterized by a decline in memory or other thinking skills. The greatest risk factor for Alzheimer’s disease is advanced age. A recent genome-wide study identified a locus on chromosome 17 associated with the age at onset, and a s...

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Detalles Bibliográficos
Autores principales: Guerreiro, Rita, Bras, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617238/
https://www.ncbi.nlm.nih.gov/pubmed/26482651
http://dx.doi.org/10.1186/s13073-015-0232-5
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author Guerreiro, Rita
Bras, Jose
author_facet Guerreiro, Rita
Bras, Jose
author_sort Guerreiro, Rita
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description Alzheimer’s disease is the most common type of dementia, and it is characterized by a decline in memory or other thinking skills. The greatest risk factor for Alzheimer’s disease is advanced age. A recent genome-wide study identified a locus on chromosome 17 associated with the age at onset, and a specific variant in CCL11 is probably responsible for the association. The association of a protective haplotype with a 10-year delay in the onset of Alzheimer’s disease and the identification of a CCL11 variant with possible functional roles in this association might allow the future development of immunomodulators with the potential to halve disease incidence.
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spelling pubmed-46172382015-10-24 The age factor in Alzheimer’s disease Guerreiro, Rita Bras, Jose Genome Med Research Highlight Alzheimer’s disease is the most common type of dementia, and it is characterized by a decline in memory or other thinking skills. The greatest risk factor for Alzheimer’s disease is advanced age. A recent genome-wide study identified a locus on chromosome 17 associated with the age at onset, and a specific variant in CCL11 is probably responsible for the association. The association of a protective haplotype with a 10-year delay in the onset of Alzheimer’s disease and the identification of a CCL11 variant with possible functional roles in this association might allow the future development of immunomodulators with the potential to halve disease incidence. BioMed Central 2015-10-20 /pmc/articles/PMC4617238/ /pubmed/26482651 http://dx.doi.org/10.1186/s13073-015-0232-5 Text en © Guerreiro and Bras. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Guerreiro, Rita
Bras, Jose
The age factor in Alzheimer’s disease
title The age factor in Alzheimer’s disease
title_full The age factor in Alzheimer’s disease
title_fullStr The age factor in Alzheimer’s disease
title_full_unstemmed The age factor in Alzheimer’s disease
title_short The age factor in Alzheimer’s disease
title_sort age factor in alzheimer’s disease
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617238/
https://www.ncbi.nlm.nih.gov/pubmed/26482651
http://dx.doi.org/10.1186/s13073-015-0232-5
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