Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactions

Protein-protein interactions are among today’s most exciting and promising targets for therapeutic intervention. To date, identifying small-molecules that selectively disrupt these interactions has proven particularly challenging for virtual screening tools, since these have typically been optimized...

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Detalles Bibliográficos
Autores principales: Bazzoli, Andrea, Kelow, Simon P., Karanicolas, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617380/
https://www.ncbi.nlm.nih.gov/pubmed/26484863
http://dx.doi.org/10.1371/journal.pone.0140359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617380/
https://www.ncbi.nlm.nih.gov/pubmed/26484863
http://dx.doi.org/10.1371/journal.pone.0140359

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