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Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss

The phosphodiesterase inhibitor (PDEI)/eNOS enhancer KMUP-1, targeting G-protein coupled receptors (GPCRs), improves dyslipidemia. We compared its lipid-lowering effects with simvastatin and explored hormone-sensitive lipase (HSL) translocation in hepatic fat loss. KMUP-1 HCl (1, 2.5, and 5 mg/kg/da...

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Detalles Bibliográficos
Autores principales:	Kuo, Kung-Kai, Wu, Bin-Nan, Liu, Chung-Pin, Yang, Tzu-Yang, Kao, Li-Pin, Wu, Jiunn-Ren, Lai, Wen-Ter, Chen, Ing-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617394/ https://www.ncbi.nlm.nih.gov/pubmed/26351364 http://dx.doi.org/10.1194/jlr.M057547

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