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Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women
Failure in antimicrobial activity contributes to high morbidity and mortality in the geriatric population. Little is known about the potential effect of resistance training (RT) on the functional properties of the innate immunity. This study aimed to investigate the influence of long-term RT on the...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617425/ https://www.ncbi.nlm.nih.gov/pubmed/26524964 http://dx.doi.org/10.1155/2015/724982 |
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author | Bartholomeu-Neto, João Brito, Ciro José Nóbrega, Otávio Toledo Sousa, Vinícius Carolino Oliveira Toledo, Juliana Silva Paula, Roberta Alves, David Junger Fonseca Ferreira, Aparecido Pimentel Franco Moraes, Clayton Córdova, Cláudio |
author_facet | Bartholomeu-Neto, João Brito, Ciro José Nóbrega, Otávio Toledo Sousa, Vinícius Carolino Oliveira Toledo, Juliana Silva Paula, Roberta Alves, David Junger Fonseca Ferreira, Aparecido Pimentel Franco Moraes, Clayton Córdova, Cláudio |
author_sort | Bartholomeu-Neto, João |
collection | PubMed |
description | Failure in antimicrobial activity contributes to high morbidity and mortality in the geriatric population. Little is known about the potential effect of resistance training (RT) on the functional properties of the innate immunity. This study aimed to investigate the influence of long-term RT on the endocytic and oxidative activities of neutrophils and monocytes in healthy older women. Our results indicate that the phagocytosis index (PhI) of neutrophils (but not of monocytes) in the RT-adapted group was significantly higher (P < 0.001; effect size, (d) = 0.90, 95% CI: [0.75–1.04]) compared to that in sedentary subjects. In contrast, the oxidative activity of either neutrophils or monocytes was not significantly influenced by RT. Also, total energy and carbohydrate intake as well as serum IL6 levels had a significant influence on the phagocytic activity of neutrophils (P = 0.04), being considered in the model. Multivariate regression identified the physical condition of the subject (β = 0.425; P = 0.01) as a significant predictor of PhI. In conclusion, circulating neutrophils of older women adapted to a long-term RT program expressed higher phagocytic activity. |
format | Online Article Text |
id | pubmed-4617425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46174252015-11-01 Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women Bartholomeu-Neto, João Brito, Ciro José Nóbrega, Otávio Toledo Sousa, Vinícius Carolino Oliveira Toledo, Juliana Silva Paula, Roberta Alves, David Junger Fonseca Ferreira, Aparecido Pimentel Franco Moraes, Clayton Córdova, Cláudio J Immunol Res Research Article Failure in antimicrobial activity contributes to high morbidity and mortality in the geriatric population. Little is known about the potential effect of resistance training (RT) on the functional properties of the innate immunity. This study aimed to investigate the influence of long-term RT on the endocytic and oxidative activities of neutrophils and monocytes in healthy older women. Our results indicate that the phagocytosis index (PhI) of neutrophils (but not of monocytes) in the RT-adapted group was significantly higher (P < 0.001; effect size, (d) = 0.90, 95% CI: [0.75–1.04]) compared to that in sedentary subjects. In contrast, the oxidative activity of either neutrophils or monocytes was not significantly influenced by RT. Also, total energy and carbohydrate intake as well as serum IL6 levels had a significant influence on the phagocytic activity of neutrophils (P = 0.04), being considered in the model. Multivariate regression identified the physical condition of the subject (β = 0.425; P = 0.01) as a significant predictor of PhI. In conclusion, circulating neutrophils of older women adapted to a long-term RT program expressed higher phagocytic activity. Hindawi Publishing Corporation 2015 2015-10-07 /pmc/articles/PMC4617425/ /pubmed/26524964 http://dx.doi.org/10.1155/2015/724982 Text en Copyright © 2015 João Bartholomeu-Neto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bartholomeu-Neto, João Brito, Ciro José Nóbrega, Otávio Toledo Sousa, Vinícius Carolino Oliveira Toledo, Juliana Silva Paula, Roberta Alves, David Junger Fonseca Ferreira, Aparecido Pimentel Franco Moraes, Clayton Córdova, Cláudio Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women |
title | Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women |
title_full | Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women |
title_fullStr | Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women |
title_full_unstemmed | Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women |
title_short | Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women |
title_sort | adaptation to resistance training is associated with higher phagocytic (but not oxidative) activity in neutrophils of older women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617425/ https://www.ncbi.nlm.nih.gov/pubmed/26524964 http://dx.doi.org/10.1155/2015/724982 |
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