Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing

BACKGROUND: The transgenic rodent mutation reporter assay provides an efficient approach to identify mutagenic agents in vivo. A major advantage of this assay is that mutant reporter transgenes can be sequenced to provide information on the mode of action of a mutagen and to identify clonally expand...

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Detalles Bibliográficos
Autores principales: Beal, Marc A., Gagné, Rémi, Williams, Andrew, Marchetti, Francesco, Yauk, Carole L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617527/
https://www.ncbi.nlm.nih.gov/pubmed/26481219
http://dx.doi.org/10.1186/s12864-015-2004-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617527/
https://www.ncbi.nlm.nih.gov/pubmed/26481219
http://dx.doi.org/10.1186/s12864-015-2004-4

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