Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region

BACKGROUND: The FOXP3 gene is the master regulator for T regulatory cells and is under tight DNA methylation control at the Treg specific demethylated region (TSDR) in its first intron. This said, methylation of its promoter region, the significance of which is unknown, has also been associated with...

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Detalles Bibliográficos
Autores principales: Bégin, Philippe, Schulze, Janika, Baron, Udo, Olek, Sven, Bauer, Rebecca N., Passerini, Laura, Baccheta, Rosa, Nadeau, Kari C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617722/
https://www.ncbi.nlm.nih.gov/pubmed/26500760
http://dx.doi.org/10.1186/s13601-015-0079-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617722/
https://www.ncbi.nlm.nih.gov/pubmed/26500760
http://dx.doi.org/10.1186/s13601-015-0079-2

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