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Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns

BACKGROUND: Phosphatidylinositol-3-kinases (PI3Ks) are a family of eukaryotic enzymes modifying phosphoinositides in phosphatidylinositols-3-phosphate. Located upstream of the AKT/mTOR signalling pathway, PI3Ks activate secondary messengers of extracellular signals. They are involved in many critica...

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Detalles Bibliográficos
Autores principales:	Philippon, Héloïse, Brochier-Armanet, Céline, Perrière, Guy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617754/ https://www.ncbi.nlm.nih.gov/pubmed/26482564 http://dx.doi.org/10.1186/s12862-015-0498-7

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