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Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs for the treatment of epileptic seizures. Although it is well known that the doses of VPA and its plasma concentrations are highly correlated, the plasma concentrations do not correlate well with the therapeutic effects of t...

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Detalles Bibliográficos
Autores principales:	Nakashima, Hiroo, Oniki, Kentaro, Nishimura, Miki, Ogusu, Naoki, Shimomasuda, Masatsugu, Ono, Tatsumasa, Matsuda, Kazuki, Yasui-Furukori, Norio, Nakagawa, Kazuko, Ishitsu, Takateru, Saruwatari, Junji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617862/ https://www.ncbi.nlm.nih.gov/pubmed/26484865 http://dx.doi.org/10.1371/journal.pone.0141266

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