Amplification at 9p in Cervical Carcinoma by Comparative Genomic Hybridization

DNA copy number changes were studied by comparative genomic hybridization on 10 tumor specimens of squamous cell carcinoma of cervix obtained from Korean patients. DNA was extracted from paraffin‐embedded sections after removal of non‐malignant cells by microdissection technique. Copy number changes...

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Autores principales: Jee, Kowan J., Kim, Young Tak, Kim, Kyu Rae, Aalto, Yan, Knuutila, Sakari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2001
Materias:
Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617954/
https://www.ncbi.nlm.nih.gov/pubmed/11455035
http://dx.doi.org/10.1155/2001/174645
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author Jee, Kowan J.
Kim, Young Tak
Kim, Kyu Rae
Aalto, Yan
Knuutila, Sakari
author_facet Jee, Kowan J.
Kim, Young Tak
Kim, Kyu Rae
Aalto, Yan
Knuutila, Sakari
author_sort Jee, Kowan J.
collection PubMed
description DNA copy number changes were studied by comparative genomic hybridization on 10 tumor specimens of squamous cell carcinoma of cervix obtained from Korean patients. DNA was extracted from paraffin‐embedded sections after removal of non‐malignant cells by microdissection technique. Copy number changes were found in 8/10 tumors. The most frequent changes were chromosome 19 gains (n=6) and losses on chromosomes 4 (n=4), 5 (n=3), and 3p (n=3). A novel finding was amplification in chromosome arm 9p21‐pter in 2 cases. Gains in 1, 3q, 5p, 6p, 8q, 16p, 17, and 20q and losses at 2q, 6q, 8p, 9q, 10p, 11, 13, 16q, and 18q were observed in at least one of the cases.
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spelling pubmed-46179542016-01-12 Amplification at 9p in Cervical Carcinoma by Comparative Genomic Hybridization Jee, Kowan J. Kim, Young Tak Kim, Kyu Rae Aalto, Yan Knuutila, Sakari Anal Cell Pathol Other DNA copy number changes were studied by comparative genomic hybridization on 10 tumor specimens of squamous cell carcinoma of cervix obtained from Korean patients. DNA was extracted from paraffin‐embedded sections after removal of non‐malignant cells by microdissection technique. Copy number changes were found in 8/10 tumors. The most frequent changes were chromosome 19 gains (n=6) and losses on chromosomes 4 (n=4), 5 (n=3), and 3p (n=3). A novel finding was amplification in chromosome arm 9p21‐pter in 2 cases. Gains in 1, 3q, 5p, 6p, 8q, 16p, 17, and 20q and losses at 2q, 6q, 8p, 9q, 10p, 11, 13, 16q, and 18q were observed in at least one of the cases. IOS Press 2001 2001-01-01 /pmc/articles/PMC4617954/ /pubmed/11455035 http://dx.doi.org/10.1155/2001/174645 Text en Copyright © 2001 Hindawi Publishing Corporation.
spellingShingle Other
Jee, Kowan J.
Kim, Young Tak
Kim, Kyu Rae
Aalto, Yan
Knuutila, Sakari
Amplification at 9p in Cervical Carcinoma by Comparative Genomic Hybridization
title Amplification at 9p in Cervical Carcinoma by Comparative Genomic Hybridization
title_full Amplification at 9p in Cervical Carcinoma by Comparative Genomic Hybridization
title_fullStr Amplification at 9p in Cervical Carcinoma by Comparative Genomic Hybridization
title_full_unstemmed Amplification at 9p in Cervical Carcinoma by Comparative Genomic Hybridization
title_short Amplification at 9p in Cervical Carcinoma by Comparative Genomic Hybridization
title_sort amplification at 9p in cervical carcinoma by comparative genomic hybridization
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617954/
https://www.ncbi.nlm.nih.gov/pubmed/11455035
http://dx.doi.org/10.1155/2001/174645
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