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JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors

RUNX1–RUNX1T1 (formerly AML1-ETO), a transcription factor generated by the t(8;21) translocation in acute myeloid leukemia (AML), dictates a leukemic program by increasing self-renewal and inhibiting differentiation. Here we demonstrate that the histone demethylase JMJD1C functions as a coactivator...

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Detalles Bibliográficos
Autores principales:	Chen, Mo, Zhu, Nan, Liu, Xiaochuan, Laurent, Benoit, Tang, Zhanyun, Eng, Rowena, Shi, Yang, Armstrong, Scott A., Roeder, Robert G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617977/ https://www.ncbi.nlm.nih.gov/pubmed/26494788 http://dx.doi.org/10.1101/gad.267278.115

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