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Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells

Mitochondrial outer membrane permeabilization (MOMP), a key step in the intrinsic apoptotic pathway, is incompletely understood. Current models emphasize the role of BH3-only BCL2 family members in BAX and BAK activation. Here we demonstrate concentration-dependent BAK autoactivation under cell-free...

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Detalles Bibliográficos
Autores principales:	Dai, Haiming, Ding, Husheng, Meng, X. Wei, Peterson, Kevin L., Schneider, Paula A., Karp, Judith E., Kaufmann, Scott H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617978/ https://www.ncbi.nlm.nih.gov/pubmed/26494789 http://dx.doi.org/10.1101/gad.267997.115

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