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CD10 Expression in Non-Small Cell Lung Cancer

CD10 is a cell surface endopeptidase that inactivates various potentially growth stimulatory peptides. In lung cancer cell lines this downregulation has been associated with increased proliferation. Downregulation of CD10 in lung cancer tissue is described, suggesting a potential role in carcinogene...

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Detalles Bibliográficos
Autores principales: Kristiansen, Glen, Schlüns, Karsten, Yongwei, Yu, Dietel, Manfred, Petersen, Iver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617995/
https://www.ncbi.nlm.nih.gov/pubmed/12122282
http://dx.doi.org/10.1155/2002/781580
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author Kristiansen, Glen
Schlüns, Karsten
Yongwei, Yu
Dietel, Manfred
Petersen, Iver
author_facet Kristiansen, Glen
Schlüns, Karsten
Yongwei, Yu
Dietel, Manfred
Petersen, Iver
author_sort Kristiansen, Glen
collection PubMed
description CD10 is a cell surface endopeptidase that inactivates various potentially growth stimulatory peptides. In lung cancer cell lines this downregulation has been associated with increased proliferation. Downregulation of CD10 in lung cancer tissue is described, suggesting a potential role in carcinogenesis and a possible use of CD10 as a prognostic marker. We aimed to determine the rate of CD10 expression in our non‐small cell lung cancer (NSCLC) collection and to clarify its correlation with clinicopathological parameters and patient survival. 114 NSCLC were analysed immunohistochemically using a monoclonal CD10 antibody (clone NCL‐CD10‐270) on an NSCLC tissue micro array. The staining was semiquantitatively scored. CD10 expression was observed in 19% of cases, without any significant association with tumour type, ‐size, ‐grading, nodal status, clinical stage, and patient survival time. We conclude that a diagnostic use of CD10 immunostaining in NSCLC is unlikely.
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spelling pubmed-46179952016-01-12 CD10 Expression in Non-Small Cell Lung Cancer Kristiansen, Glen Schlüns, Karsten Yongwei, Yu Dietel, Manfred Petersen, Iver Anal Cell Pathol Other CD10 is a cell surface endopeptidase that inactivates various potentially growth stimulatory peptides. In lung cancer cell lines this downregulation has been associated with increased proliferation. Downregulation of CD10 in lung cancer tissue is described, suggesting a potential role in carcinogenesis and a possible use of CD10 as a prognostic marker. We aimed to determine the rate of CD10 expression in our non‐small cell lung cancer (NSCLC) collection and to clarify its correlation with clinicopathological parameters and patient survival. 114 NSCLC were analysed immunohistochemically using a monoclonal CD10 antibody (clone NCL‐CD10‐270) on an NSCLC tissue micro array. The staining was semiquantitatively scored. CD10 expression was observed in 19% of cases, without any significant association with tumour type, ‐size, ‐grading, nodal status, clinical stage, and patient survival time. We conclude that a diagnostic use of CD10 immunostaining in NSCLC is unlikely. IOS Press 2002 2002-01-01 /pmc/articles/PMC4617995/ /pubmed/12122282 http://dx.doi.org/10.1155/2002/781580 Text en Copyright © 2002 Hindawi Publishing Corporation.
spellingShingle Other
Kristiansen, Glen
Schlüns, Karsten
Yongwei, Yu
Dietel, Manfred
Petersen, Iver
CD10 Expression in Non-Small Cell Lung Cancer
title CD10 Expression in Non-Small Cell Lung Cancer
title_full CD10 Expression in Non-Small Cell Lung Cancer
title_fullStr CD10 Expression in Non-Small Cell Lung Cancer
title_full_unstemmed CD10 Expression in Non-Small Cell Lung Cancer
title_short CD10 Expression in Non-Small Cell Lung Cancer
title_sort cd10 expression in non-small cell lung cancer
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617995/
https://www.ncbi.nlm.nih.gov/pubmed/12122282
http://dx.doi.org/10.1155/2002/781580
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