Runx3 specifies lineage commitment of innate lymphoid cells

Subsets of innate lymphoid cells (ILCs) reside in the mucosa and regulate immune responses against external pathogens. While ILCs can be phenotypically classified into ILC1, ILC2 and ILC3 cells, the transcriptional control of lineage commitment for each ILC subset is incompletely understood. Here we...

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Autores principales: Ebihara, Takashi, Song, Christina, Ryu, Stacy H., Plougastel-Douglas, Beatrice, Yang, Liping, Levanon, Ditsa, Groner, Yoram, Bern, Michael D., Stappenbeck, Thaddeus S., Colonna, Marco, Egawa, Takeshi, Yokoyama, Wayne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618046/
https://www.ncbi.nlm.nih.gov/pubmed/26414766
http://dx.doi.org/10.1038/ni.3272
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author Ebihara, Takashi
Song, Christina
Ryu, Stacy H.
Plougastel-Douglas, Beatrice
Yang, Liping
Levanon, Ditsa
Groner, Yoram
Bern, Michael D.
Stappenbeck, Thaddeus S.
Colonna, Marco
Egawa, Takeshi
Yokoyama, Wayne M.
author_facet Ebihara, Takashi
Song, Christina
Ryu, Stacy H.
Plougastel-Douglas, Beatrice
Yang, Liping
Levanon, Ditsa
Groner, Yoram
Bern, Michael D.
Stappenbeck, Thaddeus S.
Colonna, Marco
Egawa, Takeshi
Yokoyama, Wayne M.
author_sort Ebihara, Takashi
collection PubMed
description Subsets of innate lymphoid cells (ILCs) reside in the mucosa and regulate immune responses against external pathogens. While ILCs can be phenotypically classified into ILC1, ILC2 and ILC3 cells, the transcriptional control of lineage commitment for each ILC subset is incompletely understood. Here we report that the transcription factor Runx3 was essential for normal development of ILC1 and ILC3, but not ILC2 cells. Runx3 controlled the survival of ILC1, but not ILC3 cells. Runx3 was required for the expression of RORγt and its downstream target, aryl hydrocarbon receptor, in ILC3 cells. The absence of Runx3 in ILCs exacerbated C. rodentium infections. Therefore, our data establish Runx3 as a key transcription factor for lineage-specific differentiation of ILC1 and ILC3 cells.
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spelling pubmed-46180462016-05-01 Runx3 specifies lineage commitment of innate lymphoid cells Ebihara, Takashi Song, Christina Ryu, Stacy H. Plougastel-Douglas, Beatrice Yang, Liping Levanon, Ditsa Groner, Yoram Bern, Michael D. Stappenbeck, Thaddeus S. Colonna, Marco Egawa, Takeshi Yokoyama, Wayne M. Nat Immunol Article Subsets of innate lymphoid cells (ILCs) reside in the mucosa and regulate immune responses against external pathogens. While ILCs can be phenotypically classified into ILC1, ILC2 and ILC3 cells, the transcriptional control of lineage commitment for each ILC subset is incompletely understood. Here we report that the transcription factor Runx3 was essential for normal development of ILC1 and ILC3, but not ILC2 cells. Runx3 controlled the survival of ILC1, but not ILC3 cells. Runx3 was required for the expression of RORγt and its downstream target, aryl hydrocarbon receptor, in ILC3 cells. The absence of Runx3 in ILCs exacerbated C. rodentium infections. Therefore, our data establish Runx3 as a key transcription factor for lineage-specific differentiation of ILC1 and ILC3 cells. 2015-09-28 2015-11 /pmc/articles/PMC4618046/ /pubmed/26414766 http://dx.doi.org/10.1038/ni.3272 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ebihara, Takashi
Song, Christina
Ryu, Stacy H.
Plougastel-Douglas, Beatrice
Yang, Liping
Levanon, Ditsa
Groner, Yoram
Bern, Michael D.
Stappenbeck, Thaddeus S.
Colonna, Marco
Egawa, Takeshi
Yokoyama, Wayne M.
Runx3 specifies lineage commitment of innate lymphoid cells
title Runx3 specifies lineage commitment of innate lymphoid cells
title_full Runx3 specifies lineage commitment of innate lymphoid cells
title_fullStr Runx3 specifies lineage commitment of innate lymphoid cells
title_full_unstemmed Runx3 specifies lineage commitment of innate lymphoid cells
title_short Runx3 specifies lineage commitment of innate lymphoid cells
title_sort runx3 specifies lineage commitment of innate lymphoid cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618046/
https://www.ncbi.nlm.nih.gov/pubmed/26414766
http://dx.doi.org/10.1038/ni.3272
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