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Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer

The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-b...

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Detalles Bibliográficos
Autores principales: López de Silanes, Isabel, Paz Quesada, María, Esteller, Manel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618221/
https://www.ncbi.nlm.nih.gov/pubmed/17429137
http://dx.doi.org/10.1155/2007/586139
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author López de Silanes, Isabel
Paz Quesada, María
Esteller, Manel
author_facet López de Silanes, Isabel
Paz Quesada, María
Esteller, Manel
author_sort López de Silanes, Isabel
collection PubMed
description The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). Alterations in any of these components can lead to disease. Here, we review the mutations in 3′UTR regulatory sequences as well as the aberrant levels, subcellular localization, and posttranslational modifications of trans-acting factors that can promote or enhance the malignant phenotype of cancer cells. A thorough understanding of these alterations and their impact upon 3′UTR-directed posttranscriptional gene regulation will uncover promising new targets for therapeutic intervention.
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spelling pubmed-46182212016-01-12 Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer López de Silanes, Isabel Paz Quesada, María Esteller, Manel Cell Oncol Review The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). Alterations in any of these components can lead to disease. Here, we review the mutations in 3′UTR regulatory sequences as well as the aberrant levels, subcellular localization, and posttranslational modifications of trans-acting factors that can promote or enhance the malignant phenotype of cancer cells. A thorough understanding of these alterations and their impact upon 3′UTR-directed posttranscriptional gene regulation will uncover promising new targets for therapeutic intervention. IOS Press 2007 2007-04-03 /pmc/articles/PMC4618221/ /pubmed/17429137 http://dx.doi.org/10.1155/2007/586139 Text en Copyright © 2007 Hindawi Publishing Corporation and the authors.
spellingShingle Review
López de Silanes, Isabel
Paz Quesada, María
Esteller, Manel
Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer
title Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer
title_full Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer
title_fullStr Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer
title_full_unstemmed Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer
title_short Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer
title_sort aberrant regulation of messenger rna 3′-untranslated region in human cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618221/
https://www.ncbi.nlm.nih.gov/pubmed/17429137
http://dx.doi.org/10.1155/2007/586139
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