Notch-modifying xylosyltransferase-substrate complexes support an S(N)i-like retaining mechanism

A major remaining question in glycobiology is how a glycosyltransferase (GT) that retains the anomeric linkage of a sugar catalyzes the reaction. Xylosideα1–3 Xylosyltransferase (XXYLT1) is a retaining GT that regulates Notch receptor activation by adding xylose to the Notch extracellular domain. He...

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Detalles Bibliográficos
Autores principales: Yu, Hongjun, Takeuchi, Megumi, LeBarron, Jamie, Kantharia, Joshua, London, Erwin, Bakker, Hans, Haltiwanger, Robert S., Li, Huilin, Takeuchi, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618232/
https://www.ncbi.nlm.nih.gov/pubmed/26414444
http://dx.doi.org/10.1038/nchembio.1927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618232/
https://www.ncbi.nlm.nih.gov/pubmed/26414444
http://dx.doi.org/10.1038/nchembio.1927

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