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Notch-modifying xylosyltransferase-substrate complexes support an S(N)i-like retaining mechanism
A major remaining question in glycobiology is how a glycosyltransferase (GT) that retains the anomeric linkage of a sugar catalyzes the reaction. Xylosideα1–3 Xylosyltransferase (XXYLT1) is a retaining GT that regulates Notch receptor activation by adding xylose to the Notch extracellular domain. He...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618232/ https://www.ncbi.nlm.nih.gov/pubmed/26414444 http://dx.doi.org/10.1038/nchembio.1927 |