EGF-R is Expressed and AP-1 and NF-κ:B Are Activated in Stromal Myofibroblasts Surrounding Colon Adenocarcinomas Paralleling Expression of COX-2 and VEGF

Background: COX-2 and VEGF are important triggers of colon cancer growth, metastasis and angiogenesis. Cox-2 promoter contains transcriptional regulatory elements for AP-1 and NF-κ:B transcription factors whilst vegf is a known AP-1 downstream target gene. We investigated whether stromal myofibrobla...

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Detalles Bibliográficos
Autores principales: Konstantinopoulos, Panagiotis A., Vandoros, Gerasimos P., Karamouzis, Michalis V., Gkermpesi, Maria, Sotiropoulou-Bonikou, Georgia, Papavassiliou, Athanasios G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2007
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618411/
https://www.ncbi.nlm.nih.gov/pubmed/18032824
http://dx.doi.org/10.1155/2007/831416

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