Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency

Here we show that bivalent domains and chromosome architecture for bivalent genes are dynamically regulated during the cell cycle in human pluripotent cells. Central to this is the transient increase in H3K4-trimethylation at developmental genes during G1, thereby creating a “window of opportunity”...

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Detalles Bibliográficos
Autores principales: Singh, Amar M., Sun, Yuhua, Li, Li, Zhang, Wenjuan, Wu, Tianming, Zhao, Shaying, Qin, Zhaohui, Dalton, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618451/
https://www.ncbi.nlm.nih.gov/pubmed/26278042
http://dx.doi.org/10.1016/j.stemcr.2015.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618451/
https://www.ncbi.nlm.nih.gov/pubmed/26278042
http://dx.doi.org/10.1016/j.stemcr.2015.07.005

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