PGC Reversion to Pluripotency Involves Erasure of DNA Methylation from Imprinting Control Centers followed by Locus-Specific Re-methylation

Primordial germ cells (PGCs) are fate restricted to differentiate into gametes in vivo. However, when removed from their embryonic niche, PGCs undergo reversion to pluripotent embryonic germ cells (EGCs) in vitro. One of the major differences between EGCs and embryonic stem cells (ESCs) is variable...

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Detalles Bibliográficos
Autores principales: Oliveros-Etter, Marisabel, Li, Ziwei, Nee, Kevin, Hosohama, Linzi, Hargan-Calvopina, Joseph, Lee, Serena A., Joti, Prakash, Yu, Juehua, Clark, Amander T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618453/
https://www.ncbi.nlm.nih.gov/pubmed/26278040
http://dx.doi.org/10.1016/j.stemcr.2015.07.006

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