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Enantioselective reductive multicomponent coupling reactions between isatins and aldehydes

A metal-free stereoselective reductive coupling reaction between isatins and aldehydes is reported. The reaction relies on commercial diethyl phosphite (∼€70 kg(–1)) as the stoichiometric reductant. Base-catalyzed Pudovik addition and phosphonate/phosphate rearrangement achieved polarity inversion o...

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Detalles Bibliográficos
Autores principales:	Horwitz, Matthew A., Tanaka, Naoya, Yokosaka, Takuya, Uraguchi, Daisuke, Johnson, Jeffrey S., Ooi, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618493/ https://www.ncbi.nlm.nih.gov/pubmed/26508995 http://dx.doi.org/10.1039/c5sc02170g

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