Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

BACKGROUND: Resistance to chemotherapy is common in gastroesophageal cancer. Mechanisms of resistance are incompletely characterised and there are no predictive biomarkers in clinical practice for cytotoxic drugs. We used new cell line models to characterise novel chemotherapy resistance mechanisms...

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Detalles Bibliográficos
Autores principales: Matula, Kasia, Collie-Duguid, Elaina, Murray, Graeme, Parikh, Khyati, Grabsch, Heike, Tan, Patrick, Lalwani, Salina, Garau, Roberta, Ong, Yuhan, Bain, Gillian, Smith, Asa-Dahle, Urquhart, Gordon, Bielawski, Jacek, Finnegan, Michael, Petty, Russell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618539/
https://www.ncbi.nlm.nih.gov/pubmed/26493335
http://dx.doi.org/10.1186/s12885-015-1718-7

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