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Pegylated liposomal mitomycin C prodrug enhances tolerance of mitomycin C: a phase 1 study in advanced solid tumor patients

Mitomycin C (MMC) has potent cytotoxicity but cumulative toxicity limits widespread use. In animals, pegylated liposomal mitomycin C lipid-based prodrug (PL-MLP) was well tolerated and more effective than free MMC. We evaluated PL-MLP in patients with advanced cancer. Twenty-seven patients were trea...

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Detalles Bibliográficos
Autores principales:	Golan, Talia, Grenader, Tal, Ohana, Patricia, Amitay, Yasmine, Shmeeda, Hilary, La-Beck, Ninh M, Tahover, Esther, Berger, Raanan, Gabizon, Alberto A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Clinical Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618618/ https://www.ncbi.nlm.nih.gov/pubmed/26172205 http://dx.doi.org/10.1002/cam4.491

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