In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib

Off-target pharmacology may contribute to both adverse and beneficial effects of a new drug. In vitro pharmacological profiling is often applied early in drug discovery; there are fewer reports addressing the relevance of broad profiles to clinical adverse effects. Here, we have characterized the ph...

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Detalles Bibliográficos
Autores principales: Rolf, Michael G, Curwen, Jon O, Veldman-Jones, Margaret, Eberlein, Cath, Wang, Jianyan, Harmer, Alex, Hellawell, Caroline J, Braddock, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618646/
https://www.ncbi.nlm.nih.gov/pubmed/26516587
http://dx.doi.org/10.1002/prp2.175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618646/
https://www.ncbi.nlm.nih.gov/pubmed/26516587
http://dx.doi.org/10.1002/prp2.175

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