Cargando…
In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib
Off-target pharmacology may contribute to both adverse and beneficial effects of a new drug. In vitro pharmacological profiling is often applied early in drug discovery; there are fewer reports addressing the relevance of broad profiles to clinical adverse effects. Here, we have characterized the ph...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Ltd
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618646/ https://www.ncbi.nlm.nih.gov/pubmed/26516587 http://dx.doi.org/10.1002/prp2.175 |