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Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress

Maintaining genomic integrity during DNA replication is essential for stem cells. DNA replication origins are licensed by the MCM2–7 complexes, with most of them remaining dormant. Dormant origins (DOs) rescue replication fork stalling in S phase and ensure genome integrity. However, it is not known...

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Detalles Bibliográficos
Autores principales:	Ge, Xin Quan, Han, Jinah, Cheng, Ee-Chun, Yamaguchi, Satoru, Shima, Naoko, Thomas, Jean-Leon, Lin, Haifan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618655/ https://www.ncbi.nlm.nih.gov/pubmed/26190528 http://dx.doi.org/10.1016/j.stemcr.2015.06.002

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