Uncovering the Role of Hypermethylation by CTG Expansion in Myotonic Dystrophy Type 1 Using Mutant Human Embryonic Stem Cells

CTG repeat expansion in DMPK, the cause of myotonic dystrophy type 1 (DM1), frequently results in hypermethylation and reduced SIX5 expression. The contribution of hypermethylation to disease pathogenesis and the precise mechanism by which SIX5 expression is reduced are unknown. Using 14 different D...

Descripción completa

Detalles Bibliográficos
Autores principales: Yanovsky-Dagan, Shira, Avitzour, Michal, Altarescu, Gheona, Renbaum, Paul, Eldar-Geva, Talia, Schonberger, Oshrat, Mitrani-Rosenbaum, Stella, Levy-Lahad, Ephrat, Birnbaum, Ramon Y., Gepstein, Lior, Epsztejn-Litman, Silvina, Eiges, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618658/
https://www.ncbi.nlm.nih.gov/pubmed/26190529
http://dx.doi.org/10.1016/j.stemcr.2015.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618658/
https://www.ncbi.nlm.nih.gov/pubmed/26190529
http://dx.doi.org/10.1016/j.stemcr.2015.06.003

Ejemplares similares