Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells

BACKGROUND: Sphingomyelin (SM) and cholesterol are two types of lipid closely related biophysically. Treating the cells with exogenous sphingomyelinase (SMase) induces trafficking of cholesterol from membrane to intracellular pools and inhibition of cholesterol synthesis. In the present work, we add...

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Detalles Bibliográficos
Autores principales: Chen, Ying, Xu, Shu-Chang, Duan, Rui-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618740/
https://www.ncbi.nlm.nih.gov/pubmed/26493087
http://dx.doi.org/10.1186/s12944-015-0137-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618740/
https://www.ncbi.nlm.nih.gov/pubmed/26493087
http://dx.doi.org/10.1186/s12944-015-0137-8

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