Cargando…

TNFα-blockade stabilizes local airway hyperresponsiveness during TLR-induced exacerbations in murine model of asthma

Viral infections are a common cause of asthma exacerbation. These maladies are sometimes complicated by bacterial infections. Toll-like receptors (TLRs) are in the forefront of our microbial defence, with TLR3 responding to viral and TLR4 to bacterial stimulation. The present study was designed to e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Starkhammar, Magnus, Kumlien Georén, Susanna, Dahlén, Sven-Erik, Cardell, Lars-Olaf, Adner, Mikael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618779/ https://www.ncbi.nlm.nih.gov/pubmed/26494305 http://dx.doi.org/10.1186/s12931-015-0292-5

Ejemplares similares

Toll-Like Receptor Ligands LPS and Poly (I:C) Exacerbate Airway Hyperresponsiveness in a Model of Airway Allergy in Mice, Independently of Inflammation
por: Starkhammar, Magnus, et al.
Publicado: (2014)

Intranasal Administration of poly(I:C) and LPS in BALB/c Mice Induces Airway Hyperresponsiveness and Inflammation via Different Pathways
por: Starkhammar, Magnus, et al.
Publicado: (2012)

IL-1β induces murine airway 5-HT(2A )receptor hyperresponsiveness via a non-transcriptional MAPK-dependent mechanism
por: Zhang, Yaping, et al.
Publicado: (2007)

Innate Immune Receptors in Human Airway Smooth Muscle Cells: Activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 Agonists
por: Månsson Kvarnhammar, Anne, et al.
Publicado: (2013)

The SP‐TLR axis, which locally primes the nasal mucosa, is impeded in patients with allergic rhinitis
por: Larsson, Olivia, et al.
Publicado: (2021)

Deprived TLR9 Expression in Apparently Healthy Nasal Mucosa Might Trigger Polyp-Growth in Chronic Rhinosinusitis Patients
por: Tengroth, Lotta, et al.
Publicado: (2014)

Antigen presenting epithelial cells play a pivotal role in airway allergy
por: Arebro, Julia, et al.
Publicado: (2015)

Antigen-presenting epithelial cells can play a pivotal role in airway allergy
por: Arebro, Julia, et al.
Publicado: (2016)

The effect of MP29-02* is mediated via bitter taste receptors (TAS2R)
por: Ekstedt, Sandra, et al.
Publicado: (2015)

Effects of MP-AzeFlu enhanced by activation of bitter taste receptor TAS2R
por: Ekstedt, Sandra, et al.
Publicado: (2020)

Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo
por: Bao, Aihua, et al.
Publicado: (2017)

Interleukin 33 exacerbates antigen driven airway hyperresponsiveness, inflammation and remodeling in a mouse model of asthma
por: Sjöberg, L. C., et al.
Publicado: (2017)

Functional Effects of Toll-Like Receptor (TLR)3, 7, 9, RIG-I and MDA-5 Stimulation in Nasal Epithelial Cells
por: Tengroth, Lotta, et al.
Publicado: (2014)

Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma
por: Lei, Ying, et al.
Publicado: (2015)

Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma
por: Cloots, Roy H. E., et al.
Publicado: (2018)

Downregulation of epithelial MHC II expression in chronic rhinosinusitis with polyps
por: Arebro, Julia, et al.
Publicado: (2013)

A role for neuropeptides in innate immune inflammation of the nose
por: Larsson, Olivia, et al.
Publicado: (2015)

Upregulated expression of Notch1/4 - JAG-1/DLL-1 detected in allergic rhinitis
por: Hjalmarsson, Eric, et al.
Publicado: (2023)

Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma
por: North, Michelle L, et al.
Publicado: (2011)

Tumour-draining lymph nodes in head and neck cancer are characterized by accumulation of CTLA-4 and PD-1 expressing Treg cells
por: Piersiala, Krzysztof, et al.
Publicado: (2022)

Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps
por: Tengroth, Lotta, et al.
Publicado: (2018)

A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification
por: Arebro, Julia, et al.
Publicado: (2017)

CD4(+) and CD8(+) T cells in sentinel nodes exhibit distinct pattern of PD‐1, CD69, and HLA‐DR expression compared to tumor tissue in oral squamous cell carcinoma
por: Piersiala, Krzysztof, et al.
Publicado: (2021)

Inverse Immunological Responses Induced by Allergic Rhinitis and Head and Neck Squamous Cell Carcinoma
por: Millrud, Camilla Rydberg, et al.
Publicado: (2014)

Intralymphatic Immunotherapy (ILIT) with both grass and birch allergen- a randomized controlled trial
por: Hellkvist, Laila, et al.
Publicado: (2015)

Downregulation of peroxisome proliferator-activated receptors (PPARs) in nasal polyposis
por: Cardell, Lars-Olaf, et al.
Publicado: (2005)

Neutrophil phenotypes in bronchial airways differentiate single from dual responding allergic asthmatics
por: van der Burg, Nicole, et al.
Publicado: (2022)

Extensive qPCR analysis reveals altered gene expression in middle ear mucosa from cholesteatoma patients
por: Drakskog, Cecilia, et al.
Publicado: (2020)

A prolonged innate systemic immune response in COVID-19
por: Ekstedt, Sandra, et al.
Publicado: (2022)

S-Nitrosoglutathione Attenuates Airway Hyperresponsiveness in Murine Bronchopulmonary Dysplasia
por: Raffay, Thomas M., et al.
Publicado: (2016)

Rosmarinic Acid Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma
por: Liang, Zhengmin, et al.
Publicado: (2016)

Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways
por: Birrell, Mark A, et al.
Publicado: (2003)

Intralymphatic immunotherapy of pollen-induced rhinoconjunctivitis: a double-blind placebo-controlled trial
por: Hylander, Terese, et al.
Publicado: (2016)

Role of Estrogen Receptors α and β in a Murine Model of Asthma: Exacerbated Airway Hyperresponsiveness and Remodeling in ERβ Knockout Mice
por: Kalidhindi, Rama Satyanarayana Raju, et al.
Publicado: (2020)

Concomitant Exposure to Ovalbumin and Endotoxin Augments Airway Inflammation but Not Airway Hyperresponsiveness in a Murine Model of Asthma
por: Mac Sharry, John, et al.
Publicado: (2014)

A Novel Method Using Fine Needle Aspiration from Tumor-Draining Lymph Nodes Could Enable the Discovery of New Prognostic Markers in Patients with Cutaneous Squamous Cell Carcinoma
por: Lagebro, Vilma, et al.
Publicado: (2023)

Attenuation of allergic airway inflammation and hyperresponsiveness in a murine model of asthma by silver nanoparticles
por: Park, Hee Sun, et al.
Publicado: (2010)

Psoriasin, one of several new proteins identified in nasal lavage fluid from allergic and non-allergic individuals using 2-dimensional gel electrophoresis and mass spectrometry
por: Bryborn, Malin, et al.
Publicado: (2005)

Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis
por: Mansson, Anne, et al.
Publicado: (2006)

Airway exposure to perfluorooctanoate exacerbates airway hyperresponsiveness and downregulates glucocorticoid receptor expression in asthmatic mice
por: Zeng, Zeyu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_21k4kkmrtv60bh1kc7el8pjs4t