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Tyrosinase Overexpression Promotes ATM-Dependent p53 Phosphorylation by Quercetin and Sensitizes Melanoma Cells to Dacarbazine

Dacarbazine (DTIC) has been used for the treatment of melanoma for decades. However, monotherapy with this chemotherapeutic agent results only in moderate response rates. To improve tumor response to DTIC current clinical trials in melanoma focus on combining a novel targeted agent with chemotherapy...

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Detalles Bibliográficos
Autores principales:	Thangasamy, Thilakavathy, Sittadjody, Sivanandane, H. Limesand, Kirsten, Burd, Randy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2008
Materias:	Other
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618806/ https://www.ncbi.nlm.nih.gov/pubmed/18791269 http://dx.doi.org/10.3233/CLO-2008-0441

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