Cargando…

Tyrosinase Overexpression Promotes ATM-Dependent p53 Phosphorylation by Quercetin and Sensitizes Melanoma Cells to Dacarbazine

Dacarbazine (DTIC) has been used for the treatment of melanoma for decades. However, monotherapy with this chemotherapeutic agent results only in moderate response rates. To improve tumor response to DTIC current clinical trials in melanoma focus on combining a novel targeted agent with chemotherapy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thangasamy, Thilakavathy, Sittadjody, Sivanandane, H. Limesand, Kirsten, Burd, Randy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2008
Materias:	Other
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618806/ https://www.ncbi.nlm.nih.gov/pubmed/18791269 http://dx.doi.org/10.3233/CLO-2008-0441

Ejemplares similares

Quercetin abrogates chemoresistance in melanoma cells by modulating ΔNp73
por: Thangasamy, Thilakavathy, et al.
Publicado: (2010)

Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy
por: Harris, Zoey, et al.
Publicado: (2016)

Prognostic Value of RT-PCR Tyrosinase Detection in Peripheral Blood of Melanoma Patients
por: Carrillo, Esmeralda, et al.
Publicado: (2006)

Dacarbazine Combined Targeted Therapy versus Dacarbazine Alone in Patients with Malignant Melanoma: A Meta-Analysis
por: Jiang, Guan, et al.
Publicado: (2014)

Meta-Analysis of the Safety and Efficacy of Interferon Combined With Dacarbazine Versus Dacarbazine Alone in Cutaneous Malignant Melanoma
por: Xin, Yong, et al.
Publicado: (2016)

IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter
por: Mitchell, G C, et al.
Publicado: (2010)

A randomized phase III study comparing dacarbazine, BCNU, cisplatin and tamoxifen with dacarbazine and interferon in advanced melanoma
por: Middleton, M R, et al.
Publicado: (2000)

Phase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferon-α in advanced malignant melanoma
por: Daponte, Antonio, et al.
Publicado: (2013)

Treatment of metastatic malignant melanoma with dacarbazine, vindesine and cisplatin.
por: Pectasides, D., et al.
Publicado: (1989)

Dacarbazine nanoparticle topical delivery system for the treatment of melanoma
por: Hafeez, Abdul, et al.
Publicado: (2017)

Q-TWiST analysis comparing ipilimumab/dacarbazine vs placebo/dacarbazine for patients with stage III/IV melanoma
por: Sherrill, B, et al.
Publicado: (2013)

Novel 3D Co-Culture Model for Epithelial-Stromal Cells Interaction in Prostate Cancer
por: Fang, Xiaolan, et al.
Publicado: (2013)

Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation
por: Tang, Jun, et al.
Publicado: (2013)

Dacarbazine (DTIC)-based chemotherapy or chemoimmunotherapy of patients with disseminated malignant melanoma.
por: Mulder, N. H., et al.
Publicado: (1994)

Sequential administration of varying doses of dacarbazine and fotemustine in advanced malignant melanoma.
por: Lee, S. M., et al.
Publicado: (1993)

Nivolumab improved survival vs dacarbazine in patients with untreated advanced melanoma
por: Long, Georgina V, et al.
Publicado: (2015)

Synergistic inhibitory effects of the oxyresveratrol and dacarbazine combination against melanoma cells
por: Lee, Sang Gyu, et al.
Publicado: (2021)

Dacarbazine-Loaded Targeted Polymeric Nanoparticles for Enhancing Malignant Melanoma Therapy
por: Xiong, Wei, et al.
Publicado: (2022)

Cell-Based and Pharmacologic Hormone Therapy Maintain Diastolic Function After Ovariectomy in Hypertensive Rats
por: Groban, Leanne, et al.
Publicado: (2020)

ATM protein and p53-serine 15 phosphorylation in ataxia-telangiectasia (AT) patients and at heterozygotes
por: Delia, D, et al.
Publicado: (2000)

Correction: Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation
por: Tang, Jun, et al.
Publicado: (2013)

Phase I clinical trial of the Src inhibitor dasatinib with dacarbazine in metastatic melanoma
por: Algazi, A P, et al.
Publicado: (2012)

Restoration of radiation therapy-induced salivary gland dysfunction in mice by post therapy IGF-1 administration
por: Grundmann, Oliver, et al.
Publicado: (2010)

ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation
por: Craig, Ashley L, et al.
Publicado: (2010)

Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant
por: Lu, Banyi, et al.
Publicado: (2019)

Phase I–II study of plitidepsin and dacarbazine as first-line therapy for advanced melanoma
por: Plummer, R, et al.
Publicado: (2013)

Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma
por: Yang, Chunhua, et al.
Publicado: (2016)

miR 204-5p inhibits apoptosis in dacarbazine-treated melanoma cells
por: PALKINA, NADEZHDA, et al.
Publicado: (2022)

ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication
por: Wang, Dejie, et al.
Publicado: (2021)

Dacarbazine and the Agonistic TRAIL Receptor-2 Antibody Lexatumumab Induce Synergistic Anticancer Effects in Melanoma
por: Engesæter, Birgit, et al.
Publicado: (2012)

Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model
por: ZHANG, XIAO-HUA, et al.
Publicado: (2013)

Whole Body Microwave Irradiation for Improved Dacarbazine Therapeutical Action in Cutaneous Melanoma Mouse Model
por: Neagu, Monica, et al.
Publicado: (2013)

Combined Therapy with Dacarbazine and Hyperthermia Induces Cytotoxicity in A375 and MNT-1 Melanoma Cells
por: Salvador, Diana, et al.
Publicado: (2022)

Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response
por: Coucoravas, Christos, et al.
Publicado: (2016)

Dacarbazine (DTIC) and human recombinant interferon alpha 2a (Roferon) in the treatment of disseminated malignant melanoma.
por: Mulder, N. H., et al.
Publicado: (1990)

A patient with metastatic melanoma presenting with gastrointestinal perforation after dacarbazine infusion: a case report
por: Oosting, Sjoukje F, et al.
Publicado: (2010)

Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance
por: Malvi, Parmanand, et al.
Publicado: (2016)

Increased Infiltration of CD8(+) T Cells by Dacarbazine in a Patient with Mucosal Penile Melanoma Refractory to Nivolumab
por: Funazumi, Masato, et al.
Publicado: (2016)

Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state
por: Malvi, Parmanand, et al.
Publicado: (2018)

Effect of dacarbazine on CD44 in live melanoma cells as measured by atomic force microscopy-based nanoscopy
por: Huang, Xun, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_t04ardgpkd7c9cmvbhb5gnbdia