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Malignancy-Associated Changes in Breast Tissue Detected by Image Cytometry

In several tissues, nuclear differences have been described in normal‐appearing cells from patients with invasive carcinomas compared to cases without invasive carcinoma, a phenomenon known as malignancy‐associated changes (MACs). The aim of this study was to determine the presence of malignancy‐ass...

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Autores principales: Mommers, Ellen C. M., Poulin, Neal, Meijer, Chris J. L. M., Baak, Jan P. A., van Diest, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618828/
https://www.ncbi.nlm.nih.gov/pubmed/11205321
http://dx.doi.org/10.1155/2000/965613
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author Mommers, Ellen C. M.
Poulin, Neal
Meijer, Chris J. L. M.
Baak, Jan P. A.
van Diest, Paul J.
author_facet Mommers, Ellen C. M.
Poulin, Neal
Meijer, Chris J. L. M.
Baak, Jan P. A.
van Diest, Paul J.
author_sort Mommers, Ellen C. M.
collection PubMed
description In several tissues, nuclear differences have been described in normal‐appearing cells from patients with invasive carcinomas compared to cases without invasive carcinoma, a phenomenon known as malignancy‐associated changes (MACs). The aim of this study was to determine the presence of malignancy‐associated changes in breast tissue. Image cytometry was performed on Feulgen stained tissue sections of patients with usual ductal hyperplasia with (n=30) or without (n=41) adjacent invasive breast carcinoma. Nuclear features of normal‐appearing cells as well as of usual ductal hyperplastic cells were separately compared between the two groups. Many features of normal‐appearing epithelial cells were significantly different between cases with and without invasive cancer. Significant differences were also found by measuring ductal hyperplastic nuclei instead of normal‐appearing nuclei. Cases with or without cancer could be distinguished with a classification accuracy of 80% by discriminant analysis using 2 nuclear features derived from ductal hyperplastic cells. In conclusion, image cytometry on breast tissue sections shows that malignancy‐associated changes can be found in normal as well as in usual ductal hyperplastic breast cells. This could be clinically relevant for the detection of occult breast cancer, for the prediction of risk in these lesions, and to monitor the effect of chemopreventive agents.
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spelling pubmed-46188282016-01-12 Malignancy-Associated Changes in Breast Tissue Detected by Image Cytometry Mommers, Ellen C. M. Poulin, Neal Meijer, Chris J. L. M. Baak, Jan P. A. van Diest, Paul J. Anal Cell Pathol Other In several tissues, nuclear differences have been described in normal‐appearing cells from patients with invasive carcinomas compared to cases without invasive carcinoma, a phenomenon known as malignancy‐associated changes (MACs). The aim of this study was to determine the presence of malignancy‐associated changes in breast tissue. Image cytometry was performed on Feulgen stained tissue sections of patients with usual ductal hyperplasia with (n=30) or without (n=41) adjacent invasive breast carcinoma. Nuclear features of normal‐appearing cells as well as of usual ductal hyperplastic cells were separately compared between the two groups. Many features of normal‐appearing epithelial cells were significantly different between cases with and without invasive cancer. Significant differences were also found by measuring ductal hyperplastic nuclei instead of normal‐appearing nuclei. Cases with or without cancer could be distinguished with a classification accuracy of 80% by discriminant analysis using 2 nuclear features derived from ductal hyperplastic cells. In conclusion, image cytometry on breast tissue sections shows that malignancy‐associated changes can be found in normal as well as in usual ductal hyperplastic breast cells. This could be clinically relevant for the detection of occult breast cancer, for the prediction of risk in these lesions, and to monitor the effect of chemopreventive agents. IOS Press 2000 2000-01-01 /pmc/articles/PMC4618828/ /pubmed/11205321 http://dx.doi.org/10.1155/2000/965613 Text en Copyright © 2000 Hindawi Publishing Corporation.
spellingShingle Other
Mommers, Ellen C. M.
Poulin, Neal
Meijer, Chris J. L. M.
Baak, Jan P. A.
van Diest, Paul J.
Malignancy-Associated Changes in Breast Tissue Detected by Image Cytometry
title Malignancy-Associated Changes in Breast Tissue Detected by Image Cytometry
title_full Malignancy-Associated Changes in Breast Tissue Detected by Image Cytometry
title_fullStr Malignancy-Associated Changes in Breast Tissue Detected by Image Cytometry
title_full_unstemmed Malignancy-Associated Changes in Breast Tissue Detected by Image Cytometry
title_short Malignancy-Associated Changes in Breast Tissue Detected by Image Cytometry
title_sort malignancy-associated changes in breast tissue detected by image cytometry
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618828/
https://www.ncbi.nlm.nih.gov/pubmed/11205321
http://dx.doi.org/10.1155/2000/965613
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