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Predictive Value of Tumor Load in Breast Cancer Sentinel Lymph Nodes for Second Echelon Lymph Node Metastases
Background: The need for routine axillary lymph node dissection (ALND) in patients with invasive breast cancer and low-volume sentinel node (SN) involvement is questionable. Accurate prediction of second echelon lymph node involvement could identify those patients most likely to benefit from ALND. M...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618833/ https://www.ncbi.nlm.nih.gov/pubmed/18032826 http://dx.doi.org/10.1155/2007/570683 |
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author | van Deurzen, C. H. M. van Hillegersberg, R. Hobbelink, M. G. G. Seldenrijk, C. A. Koelemij, R. van Diest, P. J. |
author_facet | van Deurzen, C. H. M. van Hillegersberg, R. Hobbelink, M. G. G. Seldenrijk, C. A. Koelemij, R. van Diest, P. J. |
author_sort | van Deurzen, C. H. M. |
collection | PubMed |
description | Background: The need for routine axillary lymph node dissection (ALND) in patients with invasive breast cancer and low-volume sentinel node (SN) involvement is questionable. Accurate prediction of second echelon lymph node involvement could identify those patients most likely to benefit from ALND. Methods: A consecutive series of 317 patients with invasive breast cancer and a tumor positive axillary SN followed by ALND was reviewed. Clinicopathologic features of the primary tumor and the SN were assessed as possible predictors of second echelon lymph node involvement. Results: Second echelon metastases were found in 116/317 cases (36.6%). Frequency of second echelon lymph node involvement in patients with isolated tumor cells (ITC, N = 23), micro- (N = 101) and macrometastases (N = 193) was 13%, 20% and 48%, respectively (p < 0.001). Based on the area % of SN occupied by tumor no subgroup of patients could be selected with less than 20% second echelon lymph node involvement. However, none of the patients with SN ITC or micrometastases and a primary tumor size ≤1 cm (N = 12, 3.8%) had second echelon lymph node involvement. Conclusions: Accurately measured SN tumor load predicts second echelon lymph node involvement. However, even in patients with ITC, the second echelon lymph nodes are involved in 13% justifying ALND. |
format | Online Article Text |
id | pubmed-4618833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46188332016-01-12 Predictive Value of Tumor Load in Breast Cancer Sentinel Lymph Nodes for Second Echelon Lymph Node Metastases van Deurzen, C. H. M. van Hillegersberg, R. Hobbelink, M. G. G. Seldenrijk, C. A. Koelemij, R. van Diest, P. J. Cell Oncol Other Background: The need for routine axillary lymph node dissection (ALND) in patients with invasive breast cancer and low-volume sentinel node (SN) involvement is questionable. Accurate prediction of second echelon lymph node involvement could identify those patients most likely to benefit from ALND. Methods: A consecutive series of 317 patients with invasive breast cancer and a tumor positive axillary SN followed by ALND was reviewed. Clinicopathologic features of the primary tumor and the SN were assessed as possible predictors of second echelon lymph node involvement. Results: Second echelon metastases were found in 116/317 cases (36.6%). Frequency of second echelon lymph node involvement in patients with isolated tumor cells (ITC, N = 23), micro- (N = 101) and macrometastases (N = 193) was 13%, 20% and 48%, respectively (p < 0.001). Based on the area % of SN occupied by tumor no subgroup of patients could be selected with less than 20% second echelon lymph node involvement. However, none of the patients with SN ITC or micrometastases and a primary tumor size ≤1 cm (N = 12, 3.8%) had second echelon lymph node involvement. Conclusions: Accurately measured SN tumor load predicts second echelon lymph node involvement. However, even in patients with ITC, the second echelon lymph nodes are involved in 13% justifying ALND. IOS Press 2007 2007-11-21 /pmc/articles/PMC4618833/ /pubmed/18032826 http://dx.doi.org/10.1155/2007/570683 Text en Copyright © 2007 Hindawi Publishing Corporation and the authors. |
spellingShingle | Other van Deurzen, C. H. M. van Hillegersberg, R. Hobbelink, M. G. G. Seldenrijk, C. A. Koelemij, R. van Diest, P. J. Predictive Value of Tumor Load in Breast Cancer Sentinel Lymph Nodes for Second Echelon Lymph Node Metastases |
title | Predictive Value of Tumor Load in Breast Cancer Sentinel Lymph Nodes for Second Echelon Lymph Node Metastases |
title_full | Predictive Value of Tumor Load in Breast Cancer Sentinel Lymph Nodes for Second Echelon Lymph Node Metastases |
title_fullStr | Predictive Value of Tumor Load in Breast Cancer Sentinel Lymph Nodes for Second Echelon Lymph Node Metastases |
title_full_unstemmed | Predictive Value of Tumor Load in Breast Cancer Sentinel Lymph Nodes for Second Echelon Lymph Node Metastases |
title_short | Predictive Value of Tumor Load in Breast Cancer Sentinel Lymph Nodes for Second Echelon Lymph Node Metastases |
title_sort | predictive value of tumor load in breast cancer sentinel lymph nodes for second echelon lymph node metastases |
topic | Other |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618833/ https://www.ncbi.nlm.nih.gov/pubmed/18032826 http://dx.doi.org/10.1155/2007/570683 |
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