Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast

We studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21–23 as the minim...

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Autores principales: Jee, Kowan J., Gong, Gyungyub, Ahn, Sei Hyun, Park, Jeong Mi, Knuutila, Sakari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2003
Materias:
Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618897/
https://www.ncbi.nlm.nih.gov/pubmed/12632018
http://dx.doi.org/10.1155/2003/803192
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author Jee, Kowan J.
Gong, Gyungyub
Ahn, Sei Hyun
Park, Jeong Mi
Knuutila, Sakari
author_facet Jee, Kowan J.
Gong, Gyungyub
Ahn, Sei Hyun
Park, Jeong Mi
Knuutila, Sakari
author_sort Jee, Kowan J.
collection PubMed
description We studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21–23 as the minimal overlapping area was seen in 12 cases (55%). The gain was observed both in benign and malignant tumours. Our study did not reveal any DNA copy number changes or allelic loss on 3p. The results suggest that DNA copy number changes are not associated with the histological grade or clinical behaviour of PT and the chromosomal changes on 3p appear to be rare. Colour figure can be viewed on http://www.esacp.org/acp/2003/25‐2/jee.htm.
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spelling pubmed-46188972016-01-12 Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast Jee, Kowan J. Gong, Gyungyub Ahn, Sei Hyun Park, Jeong Mi Knuutila, Sakari Anal Cell Pathol Other We studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21–23 as the minimal overlapping area was seen in 12 cases (55%). The gain was observed both in benign and malignant tumours. Our study did not reveal any DNA copy number changes or allelic loss on 3p. The results suggest that DNA copy number changes are not associated with the histological grade or clinical behaviour of PT and the chromosomal changes on 3p appear to be rare. Colour figure can be viewed on http://www.esacp.org/acp/2003/25‐2/jee.htm. IOS Press 2003 2003-01-01 /pmc/articles/PMC4618897/ /pubmed/12632018 http://dx.doi.org/10.1155/2003/803192 Text en Copyright © 2003 Hindawi Publishing Corporation.
spellingShingle Other
Jee, Kowan J.
Gong, Gyungyub
Ahn, Sei Hyun
Park, Jeong Mi
Knuutila, Sakari
Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast
title Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast
title_full Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast
title_fullStr Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast
title_full_unstemmed Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast
title_short Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast
title_sort gain in 1q is a common abnormality in phyllodes tumours of the breast
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618897/
https://www.ncbi.nlm.nih.gov/pubmed/12632018
http://dx.doi.org/10.1155/2003/803192
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