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Hypermethylation of the FANCC and FANCL Promoter Regions in Sporadic Acute Leukaemia

Objective: Inactivation of the FA-BRCA pathway results in chromosomal instability. Fanconi anaemia (FA) patients have an inherited defect in this pathway and are strongly predisposed to the development of acute myeloid leukaemia (AML). Studies in sporadic cancers have shown promoter methylation of t...

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Detalles Bibliográficos
Autores principales:	Hess, C. J., Ameziane, N., Schuurhuis, G. J., Errami, A., Denkers, F., Kaspers, G. J. L., Cloos, J., Joenje, H., Reinhardt, D., Ossenkoppele, G. J., Zwaan, C. M., Waisfisz, Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2008
Materias:	Other
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618910/ https://www.ncbi.nlm.nih.gov/pubmed/18607065 http://dx.doi.org/10.3233/CLO-2008-0426

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