Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine

BACKGROUND: For over two decades, a racemic mixture of oxamniquine (OXA) was administered to patients infected by Schistosoma mansoni, but whether one or both enantiomers exert antischistosomal activity was unknown. Recently, a ~30 kDa S. m ansoni sulfotransferase (SmSULT) was identified as the targ...

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Detalles Bibliográficos
Autores principales: Taylor, Alexander B., Pica-Mattoccia, Livia, Polcaro, Chiara M., Donati, Enrica, Cao, Xiaohang, Basso, Annalisa, Guidi, Alessandra, Rugel, Anastasia R., Holloway, Stephen P., Anderson, Timothy J. C., Hart, P. John, Cioli, Donato, LoVerde, Philip T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618941/
https://www.ncbi.nlm.nih.gov/pubmed/26485649
http://dx.doi.org/10.1371/journal.pntd.0004132

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