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Quantitation of Monoclonal Plasma Cells in Bone Marrow Biopsies in Plasma Cell Dyscrasia
Direct measurement of monoclonal plasma cell mass in bone marrow biopsies may be a useful parameter to establish in plasma cell dyscrasia. In this study monoclonal plasma cells/mm(2) in light chain immunoglobulin immunostained archival bone marrow sections from 22 patients in whom a diagnosis of mul...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618990/ https://www.ncbi.nlm.nih.gov/pubmed/14501083 http://dx.doi.org/10.1155/2003/821978 |
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author | Markey, G. M. Kettle, P. Morris, T. C. M. Connolly, N. Foster, H. |
author_facet | Markey, G. M. Kettle, P. Morris, T. C. M. Connolly, N. Foster, H. |
author_sort | Markey, G. M. |
collection | PubMed |
description | Direct measurement of monoclonal plasma cell mass in bone marrow biopsies may be a useful parameter to establish in plasma cell dyscrasia. In this study monoclonal plasma cells/mm(2) in light chain immunoglobulin immunostained archival bone marrow sections from 22 patients in whom a diagnosis of multiple myeloma (MM) had been excluded but who had monoclonal proteins were counted by two observers at light microscopic level. There was good correlation between the counts of the two observers. The levels of monoclonal plasma cells/mm(2) in biopsies were not related to the % counts in the aspirates taken at the same time as the biopsies. Three of seven patients with biopsy levels in excess of the polyclonal levels in patients without plasma cell dyscrasia developed progressive MM within the observation time. Monoclonal plasma cell levels/mm(2) of bone marrow biopsies can be measured and they provide a useful parameter for the assessment of patients with low volume plasma cell dyscrasia. Colour figure can be viewed on http://www.esacp.org/acp/2003/25‐4/markey.htm. |
format | Online Article Text |
id | pubmed-4618990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46189902016-01-12 Quantitation of Monoclonal Plasma Cells in Bone Marrow Biopsies in Plasma Cell Dyscrasia Markey, G. M. Kettle, P. Morris, T. C. M. Connolly, N. Foster, H. Anal Cell Pathol Other Direct measurement of monoclonal plasma cell mass in bone marrow biopsies may be a useful parameter to establish in plasma cell dyscrasia. In this study monoclonal plasma cells/mm(2) in light chain immunoglobulin immunostained archival bone marrow sections from 22 patients in whom a diagnosis of multiple myeloma (MM) had been excluded but who had monoclonal proteins were counted by two observers at light microscopic level. There was good correlation between the counts of the two observers. The levels of monoclonal plasma cells/mm(2) in biopsies were not related to the % counts in the aspirates taken at the same time as the biopsies. Three of seven patients with biopsy levels in excess of the polyclonal levels in patients without plasma cell dyscrasia developed progressive MM within the observation time. Monoclonal plasma cell levels/mm(2) of bone marrow biopsies can be measured and they provide a useful parameter for the assessment of patients with low volume plasma cell dyscrasia. Colour figure can be viewed on http://www.esacp.org/acp/2003/25‐4/markey.htm. IOS Press 2003 2003-01-01 /pmc/articles/PMC4618990/ /pubmed/14501083 http://dx.doi.org/10.1155/2003/821978 Text en Copyright © 2003 Hindawi Publishing Corporation. |
spellingShingle | Other Markey, G. M. Kettle, P. Morris, T. C. M. Connolly, N. Foster, H. Quantitation of Monoclonal Plasma Cells in Bone Marrow Biopsies in Plasma Cell Dyscrasia |
title | Quantitation of Monoclonal Plasma Cells in Bone Marrow Biopsies in Plasma Cell Dyscrasia |
title_full | Quantitation of Monoclonal Plasma Cells in Bone Marrow Biopsies in Plasma Cell Dyscrasia |
title_fullStr | Quantitation of Monoclonal Plasma Cells in Bone Marrow Biopsies in Plasma Cell Dyscrasia |
title_full_unstemmed | Quantitation of Monoclonal Plasma Cells in Bone Marrow Biopsies in Plasma Cell Dyscrasia |
title_short | Quantitation of Monoclonal Plasma Cells in Bone Marrow Biopsies in Plasma Cell Dyscrasia |
title_sort | quantitation of monoclonal plasma cells in bone marrow biopsies in plasma cell dyscrasia |
topic | Other |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618990/ https://www.ncbi.nlm.nih.gov/pubmed/14501083 http://dx.doi.org/10.1155/2003/821978 |
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