Pla2g2a Attenuates Colon Tumorigenesis in Azoxymethane-Treated C57BL/6 Mice; Expression Studies Reveal Pla2g2a Target Genes and Pathways

Background: The group IIA secretory phospholipase A2 gene, Pla2g2a, confers resistance to intestinal tumorigenesis in the Apc(Min/+) mouse model. However, it is unclear how Pla2g2a exerts its tumor-suppressive effects and whether its mode of action depends on Apc-germline mutations. Methods: We test...

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Detalles Bibliográficos
Autores principales: Fijneman, Remond J. A., Bade, Lindsey K., Peham, Johannes R., van de Wiel, Mark A., van Hinsbergh, Victor W. M., Meijer, Gerrit A., O’Sullivan, Michael G., Cormier, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2009
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619055/
https://www.ncbi.nlm.nih.gov/pubmed/19759415
http://dx.doi.org/10.3233/CLO-2009-0480

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