Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia

Background: The pTα/preTCR regulates the β-selection, a crucial T-cell developmental checkpoint, providing a most potent survival advantage to thymocytes mediated by the src-kinase p56(Lck). Methods: To define the relevance of pTα in human T-cell lymphoblastic leukemia (T-ALL), we analyzed in T-ALL...

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Detalles Bibliográficos
Autores principales: Ivanyi, Philipp, Morgan, Michael, Piao, Wenji, Ukena, Sya N., Steube, Klaus, Ganser, Arnold, Franzke, Anke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2010
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619105/
https://www.ncbi.nlm.nih.gov/pubmed/20208138
http://dx.doi.org/10.3233/CLO-2009-0500

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