Cargando…

Effect of isoniazid preventive therapy on immune responses to mycobacterium tuberculosis: an open label randomised, controlled, exploratory study

BACKGROUND: With the renewed emphasis to implement isoniazid preventive therapy (IPT) in Sub-Saharan Africa, we investigated the effect of IPT on immunological profiles among household contacts with latent tuberculosis. METHODS: Household contacts of confirmed tuberculosis patients were tested for l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Biraro, Irene Andia, Egesa, Moses, Kimuda, Simon, Smith, Steven G., Toulza, Frederic, Levin, Jonathan, Joloba, Moses, Katamba, Achilles, Cose, Stephen, Dockrell, Hazel M., Elliott, Alison M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619204/ https://www.ncbi.nlm.nih.gov/pubmed/26493989 http://dx.doi.org/10.1186/s12879-015-1201-8

Ejemplares similares

Impact of Co-Infections and BCG Immunisation on Immune Responses among Household Contacts of Tuberculosis Patients in a Ugandan Cohort
por: Biraro, Irene A., et al.
Publicado: (2014)

The Use of Interferon Gamma Inducible Protein 10 as a Potential Biomarker in the Diagnosis of Latent Tuberculosis Infection in Uganda
por: Biraro, Irene Andia, et al.
Publicado: (2016)

Use of QuantiFERON®-TB Gold in-tube culture supernatants for measurement of antibody responses
por: Kimuda, Simon G., et al.
Publicado: (2017)

Mycobacterium tuberculosis infection is associated with increased B cell responses to unrelated pathogens
por: Kimuda, Simon G., et al.
Publicado: (2020)

Characterising antibody avidity in individuals of varied Mycobacterium tuberculosis infection status using surface plasmon resonance
por: Kimuda, Simon G., et al.
Publicado: (2018)

The impact of maternal infection with Mycobacterium tuberculosis on the infant response to bacille Calmette–Guérin immunization
por: Mawa, Patrice A., et al.
Publicado: (2015)

Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection
por: Kimuda, Simon G., et al.
Publicado: (2017)

Circulating B-Lymphocytes as Potential Biomarkers of Tuberculosis Infection Activity
por: Sebina, Ismail, et al.
Publicado: (2014)

Mycobacterium tuberculosis Uganda II is more susceptible to rifampicin and isoniazid compared to Beijing and Delhi/CAS families
por: Kasule, George W., et al.
Publicado: (2016)

Type 2 Diabetes Mellitus and Latent Tuberculosis Infection Moderately Influence Innate Lymphoid Cell Immune Responses in Uganda
por: Ssekamatte, Phillip, et al.
Publicado: (2021)

Evaluation of Xpert(®) MTB/XDR test for susceptibility testing of Mycobacterium tuberculosis to first and second-line drugs in Uganda
por: Katamba, Achilles, et al.
Publicado: (2023)

Evaluation of Xpert MTB/XDR test for susceptibility testing of Mycobacterium tuberculosis to first and second-line drugs in Uganda
por: Katamba, Achilles, et al.
Publicado: (2023)

Incremental Yield of Serial Sputum Cultures for Diagnosis of Tuberculosis among HIV Infected Smear Negative Pulmonary TB Suspects in Kampala, Uganda
por: Ssengooba, Willy, et al.
Publicado: (2012)

Accuracy of different Xpert MTB/Rif implementation strategies in programmatic settings at the regional referral hospitals in Uganda: Evidence for country wide roll out
por: Muttamba, Winters, et al.
Publicado: (2018)

Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda
por: Kigozi, Edgar, et al.
Publicado: (2018)

Optimizing Tuberculosis Case Detection through a Novel Diagnostic Device Placement Model: The Case of Uganda
por: Pho, Mai T., et al.
Publicado: (2015)

Health seeking behavior among individuals presenting with chronic cough at referral hospitals in Uganda; Missed opportunity for early tuberculosis diagnosis
por: Muttamba, Winters, et al.
Publicado: (2019)

Hypovitaminosis D among newly diagnosed pulmonary TB patients and their household contacts in Uganda
por: Acen, Ester Lilian, et al.
Publicado: (2022)

Impact of vitamin D status and cathelicidin antimicrobial peptide on adults with active pulmonary TB globally: A systematic review and meta-analysis
por: Acen, Ester Lilian, et al.
Publicado: (2021)

Evaluation of circulating serum cathelicidin levels as a potential biomarker to discriminate between active and latent tuberculosis in Uganda
por: Acen, Ester Lilian, et al.
Publicado: (2022)

Investigating the non-specific effects of BCG vaccination on the innate immune system in Ugandan neonates: study protocol for a randomised controlled trial
por: Prentice, Sarah, et al.
Publicado: (2015)

Correction to: Investigating the non-specific effects of BCG vaccination on the innate immune system in Ugandan neonates: study protocol for a randomised controlled trial
por: Prentice, Sarah, et al.
Publicado: (2020)

Association of circulating serum free bioavailable and total vitamin D with cathelicidin levels among active TB patients and household contacts
por: Acen, Ester Lilian, et al.
Publicado: (2023)

Post-immunization leucocytosis and its implications for the management of febrile infants
por: Prentice, Sarah, et al.
Publicado: (2018)

Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
por: Nabatanzi, Rose, et al.
Publicado: (2018)

Implementation science to improve the quality of tuberculosis diagnostic services in Uganda
por: Cattamanchi, Adithya, et al.
Publicado: (2019)

Comparison of GeneXpert cycle threshold values with smear microscopy and culture as a measure of mycobacterial burden in five regional referral hospitals of Uganda- A cross-sectional study
por: Najjingo, Irene, et al.
Publicado: (2019)

Career development for infection and immunity research in Uganda: a decade of experience from the Makerere University – Uganda Virus Research Institute research and training programme
por: Nakanjako, Damalie, et al.
Publicado: (2020)

Immunology in Africa
por: Cose, Stephen, et al.
Publicado: (2015)

Risk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda
por: Koopman, Jan Pieter, et al.
Publicado: (2019)

Predominance of Uganda genotype of Mycobacterium tuberculosis isolated from Ugandan patients with tuberculous lymphadenitis
por: Wamala, Dan, et al.
Publicado: (2015)

Multicenter Study of the Accuracy of the BD MAX Multidrug-resistant Tuberculosis Assay for Detection of Mycobacterium tuberculosis Complex and Mutations Associated With Resistance to Rifampin and Isoniazid
por: Shah, Maunank, et al.
Publicado: (2020)

Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda
por: Lubyayi, Lawrence, et al.
Publicado: (2020)

Minimum inhibitory concentrations of rifampin and isoniazid among multidrug and isoniazid resistant Mycobacterium tuberculosis in Ethiopia
por: Getahun, Muluwork, et al.
Publicado: (2022)

Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort
por: Nabatanzi, Rose, et al.
Publicado: (2019)

Monocyte Dysfunction, Activation, and Inflammation After Long-Term Antiretroviral Therapy in an African Cohort
por: Nabatanzi, Rose, et al.
Publicado: (2019)

Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
por: Nabatanzi, Rose, et al.
Publicado: (2021)

Ethical and practical considerations arising from community consultation on implementing controlled human infection studies using Schistosoma mansoni in Uganda
por: Egesa, Moses, et al.
Publicado: (2022)

Immune Responses Following BCG Immunization of Infants in Uganda and United Kingdom Are Similar for Purified Protein Derivative but Differ for Secretory Proteins of Mycobacterium tuberculosis
por: Mawa, Patrice A., et al.
Publicado: (2021)

Rifapentine and isoniazid for prevention of tuberculosis in people with diabetes (PROTID): protocol for a randomised controlled trial
por: Ntinginya, Nyanda Elias, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_af0773c4tglkphgi0ofib2labg