A Peptide Antagonist of the ErbB1 Receptor Inhibits Receptor Activation, Tumor Cell Growth and Migration In Vitro and Xenograft Tumor Growth In Vivo

The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in tumorigenesis and cancer disease progression, and therefore has become an attractive target for structure-based drug design. ErbB receptors are activated by ligand-induced homo- and heterodimerization. S...

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Detalles Bibliográficos
Autores principales: Xu, Ruodan, Povlsen, Gro Klitgaard, Soroka, Vladislav, Bock, Elisabeth, Berezin, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2010
Materias:
Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619243/
https://www.ncbi.nlm.nih.gov/pubmed/20364069
http://dx.doi.org/10.3233/CLO-2010-0515

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