The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2

BACKGROUND: Lafora disease (LD, OMIM 254780) is a fatal neurodegenerative disorder produced mainly by mutations in two genes: EPM2A, encoding the dual specificity phosphatase laforin, and EPM2B, encoding the E3-ubiquitin ligase malin. Although it is known that laforin and malin may form a functional...

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Detalles Bibliográficos
Autores principales: Viana, Rosa, Lujan, Pablo, Sanz, Pascual
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619252/
https://www.ncbi.nlm.nih.gov/pubmed/26493215
http://dx.doi.org/10.1186/s12858-015-0053-6

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