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Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab

BACKGROUND: Clinical targeting of TNFR family of receptors (CD40, CD134 and CD137) with immunostimulatory monoclonal antibodies has been successful in cancer immunotherapy. However, targeting of CD27 with a mAb is a relatively new approach to provide costimulation of immune cells undergoing activati...

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Detalles Bibliográficos
Autores principales:	Ramakrishna, Venky, Sundarapandiyan, Karuna, Zhao, Biwei, Bylesjo, Max, Marsh, Henry C., Keler, Tibor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619281/ https://www.ncbi.nlm.nih.gov/pubmed/26500773 http://dx.doi.org/10.1186/s40425-015-0080-2

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