Relevance of Germline Mutation Screening in Both Familial and Sporadic Head and Neck Paraganglioma for Early Diagnosis and Clinical Management

Background: Head and neck paraganglioma (PGL) are benign tumors that can cause important direct or surgery induced morbidity. Almost all familial and 11–29% of sporadic PGL are caused by inactivating germline mutations in succinate dehydrogenase (SDH) genes. Our aim was to screen for such mutations...

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Detalles Bibliográficos
Autores principales: Hermsen, Mario A., Sevilla, María A., Llorente, José Luis, Weiss, Marjan M., Grimbergen, Anneliese, Allonca, Eva, Garcia-Inclán, Cristina, Balbín, Milagros, Suárez, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2010
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619289/
https://www.ncbi.nlm.nih.gov/pubmed/20208144
http://dx.doi.org/10.3233/CLO-2009-0498

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