Promiscuous Behavior of HPV16E6 Specific T Cell Receptor Beta Chains Hampers Functional Expression in TCR Transgenic T Cells, Which Can Be Restored in Part by Genetic Modification

Background: T cell receptor gene transfer is a promising strategy to treat patients suffering from HPV induced malignancies. Therefore we isolated the TCRαβ open reading frames of an HPV16E6 specific CTL clone and generated TCR transgenic T cells. In general low level expression of the transgenic TC...

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Detalles Bibliográficos
Autores principales: Scholten, Kirsten B. J., Ruizendaal, Janneke J., Graf, Marcus, Schoedl, Thomas, Kramer, Duco, Meijer, Chris J. L. M., Man, Stephen, Hooijberg, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2010
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619291/
https://www.ncbi.nlm.nih.gov/pubmed/20208133
http://dx.doi.org/10.3233/CLO-2009-0493

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