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The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows

BACKGROUND: Negative energy balance (NEB) is a common pathological foundation of ketosis and fatty liver. Liver and fat tissue are the major organs of lipid metabolism and take part in modulating lipid oxidative capacity and energy demands, which is also a key metabolic pathway that regulates NEB de...

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Autores principales: Xu, Chuang, Xu, Qiushi, Chen, Yuanyuan, Yang, Wei, Xia, Cheng, Yu, Hongjiang, Zhu, Kuilin, Shen, Taiyu, Zhang, Ziyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619293/
https://www.ncbi.nlm.nih.gov/pubmed/26497746
http://dx.doi.org/10.1186/s12917-015-0585-4
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author Xu, Chuang
Xu, Qiushi
Chen, Yuanyuan
Yang, Wei
Xia, Cheng
Yu, Hongjiang
Zhu, Kuilin
Shen, Taiyu
Zhang, Ziyang
author_facet Xu, Chuang
Xu, Qiushi
Chen, Yuanyuan
Yang, Wei
Xia, Cheng
Yu, Hongjiang
Zhu, Kuilin
Shen, Taiyu
Zhang, Ziyang
author_sort Xu, Chuang
collection PubMed
description BACKGROUND: Negative energy balance (NEB) is a common pathological foundation of ketosis and fatty liver. Liver and fat tissue are the major organs of lipid metabolism and take part in modulating lipid oxidative capacity and energy demands, which is also a key metabolic pathway that regulates NEB develop during perinatal period. Fibroblast growth factor-21 (FGF-21) is a recently discovered protein hormone that plays an important and specific regulating role in adipose lipid metabolism and liver gluconeogenesis for human and mouse. Our aim is to investigate the variation and relationship between serum FGF-21 concentration and characteristic parameters related to negative energy balance in different energy metabolism state. METHODS: In this research, five non-pregnant, non-lactating Holstein–Friesian dairy cows were randomly allocated into two groups. The interventions were a controlled-energy diet (30 % of maintenance energy requirements) and a moderate-energy diet (120 % of predicted energy requirements) that lasted for the duration of the experiment. We measured biochemical parameters, serum FGF-21, leptin and insulin levels by commercial ELISA kits. RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low. FGF-21 levels exhibited a significant positive correlation with serum leptin levels, while an inverse relationship was found between FGF-21 and blood glucose and β-hydroxybutyrate acid (BHBA) levels. CONCLUSION: An increase in FGF-21 levels after a controlled-energy diet treatment may contribute to a positive metabolic effect which could result in a new theoretical and practical basis for the preventive strategy of dairy cows with NEB.
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spelling pubmed-46192932015-10-26 The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows Xu, Chuang Xu, Qiushi Chen, Yuanyuan Yang, Wei Xia, Cheng Yu, Hongjiang Zhu, Kuilin Shen, Taiyu Zhang, Ziyang BMC Vet Res Research Article BACKGROUND: Negative energy balance (NEB) is a common pathological foundation of ketosis and fatty liver. Liver and fat tissue are the major organs of lipid metabolism and take part in modulating lipid oxidative capacity and energy demands, which is also a key metabolic pathway that regulates NEB develop during perinatal period. Fibroblast growth factor-21 (FGF-21) is a recently discovered protein hormone that plays an important and specific regulating role in adipose lipid metabolism and liver gluconeogenesis for human and mouse. Our aim is to investigate the variation and relationship between serum FGF-21 concentration and characteristic parameters related to negative energy balance in different energy metabolism state. METHODS: In this research, five non-pregnant, non-lactating Holstein–Friesian dairy cows were randomly allocated into two groups. The interventions were a controlled-energy diet (30 % of maintenance energy requirements) and a moderate-energy diet (120 % of predicted energy requirements) that lasted for the duration of the experiment. We measured biochemical parameters, serum FGF-21, leptin and insulin levels by commercial ELISA kits. RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low. FGF-21 levels exhibited a significant positive correlation with serum leptin levels, while an inverse relationship was found between FGF-21 and blood glucose and β-hydroxybutyrate acid (BHBA) levels. CONCLUSION: An increase in FGF-21 levels after a controlled-energy diet treatment may contribute to a positive metabolic effect which could result in a new theoretical and practical basis for the preventive strategy of dairy cows with NEB. BioMed Central 2015-10-24 /pmc/articles/PMC4619293/ /pubmed/26497746 http://dx.doi.org/10.1186/s12917-015-0585-4 Text en © Xu et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Xu, Chuang
Xu, Qiushi
Chen, Yuanyuan
Yang, Wei
Xia, Cheng
Yu, Hongjiang
Zhu, Kuilin
Shen, Taiyu
Zhang, Ziyang
The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows
title The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows
title_full The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows
title_fullStr The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows
title_full_unstemmed The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows
title_short The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows
title_sort relationship between fibroblast growth factor-21 and characteristic parameters related to energy balance in dairy cows
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619293/
https://www.ncbi.nlm.nih.gov/pubmed/26497746
http://dx.doi.org/10.1186/s12917-015-0585-4
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