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Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization

BACKGROUND: The mitogen-activated protein kinases (MAPK) and the phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathways are intertwined on various levels and simultaneous inhibition reduces tumorsize and prolonges survival synergistically. Furthermore, inhibiting these pa...

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Detalles Bibliográficos
Autores principales:	Kuger, Sebastian, Flentje, Michael, Djuzenova, Cholpon S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619315/ https://www.ncbi.nlm.nih.gov/pubmed/26498922 http://dx.doi.org/10.1186/s13014-015-0514-5

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