HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

BACKGROUND: Understanding carboplatin resistance in ovarian cancer is critical for the improvement of patients’ lives. Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of a cancer are integrally involved in pathways conferring chemo-resistance. Long...

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Detalles Bibliográficos
Autores principales: Teschendorff, Andrew E., Lee, Shih-Han, Jones, Allison, Fiegl, Heidi, Kalwa, Marie, Wagner, Wolfgang, Chindera, Kantaraja, Evans, Iona, Dubeau, Louis, Orjalo, Arturo, Horlings, Hugo M., Niederreiter, Lukas, Kaser, Arthur, Yang, Winnie, Goode, Ellen L., Fridley, Brooke L., Jenner, Richard G., Berns, Els M.J.J., Wik, Elisabeth, Salvesen, Helga B., Wisman, G. Bea A., van der Zee, Ate G.J., Davidson, Ben, Trope, Claes G., Lambrechts, Sandrina, Vergote, Ignace, Calvert, Hilary, Jacobs, Ian J., Widschwendter, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619324/
https://www.ncbi.nlm.nih.gov/pubmed/26497652
http://dx.doi.org/10.1186/s13073-015-0233-4

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