A framework for retinal vasculature segmentation based on matched filters

BACKGROUND: Automatic fundus image processing plays a significant role in computer-assisted retinopathy diagnosis. As retinal vasculature is an important anatomical structure in ophthalmic images, recently, retinal vasculature segmentation has received considerable attention from researchers. A segmentation method usually consists of three steps: preprocessing, segmentation, post-processing. Most of the existing methods emphasize on the segmentation step. In our opinion, the vessels and background can be easily separable when suitable preprocessing exists. METHODS: This paper represents a new matched filter-based vasculature segmentation method for 2-D retinal images. First of all, a raw segmentation is acquired by thresholding the images preprocessed using weighted improved circular gabor filter and multi-directional multi-scale second derivation of Gaussian. After that, the raw segmented image is fine-tuned by a set of novel elongating filters. Finally, we eliminate the speckle like regions and isolated pixels, most of which are non-vessel noises and miss-classified fovea or pathological regions. RESULTS: The performance of the proposed method is examined on two popularly used benchmark databases: DRIVE and STARE. The accuracy values are 95.29 and 95.69 %, respectively, without a significant degradation of specificity and sensitivity. CONCLUSION: The performance of the proposed method is significantly better than almost all unsupervised methods, in addition, comparable to most of the existing supervised vasculature segmentation methods.