Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice

BACKGROUND: Stem cells of intensely regenerative tissues are susceptible to cellular damage. Although the response to this process in hematopoietic stem cells (HSCs) is crucial, the mechanisms by which hematopoietic homeostasis is sustained are not completely understood. Aging increases reactive oxy...

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Detalles Bibliográficos
Autores principales: Porto, Marcella L., Rodrigues, Bianca P., Menezes, Thiago N., Ceschim, Sara L., Casarini, Dulce E., Gava, Agata L., Pereira, Thiago Melo C., Vasquez, Elisardo C., Campagnaro, Bianca P., Meyrelles, Silvana S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619579/
https://www.ncbi.nlm.nih.gov/pubmed/26498041
http://dx.doi.org/10.1186/s12929-015-0201-8

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