Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis

Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs760537...

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Detalles Bibliográficos
Autores principales: Lu, Hsing-Fang, Hung, Kuo-Sheng, Hsu, Yu-Wen, Tai, Yu-Ting, Huang, Lin-Shan, Wang, Yu-Jia, Wong, Henry Sung-Ching, Hsu, Yi-Hsiang, Chang, Wei-Chiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619591/
https://www.ncbi.nlm.nih.gov/pubmed/26492493
http://dx.doi.org/10.1371/journal.pone.0140549
Descripción
Sumario:Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.

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